Police are investigating a serious road traffic collision which occurred on Steel Brow in Frizington.
Emergency services were called at 4:35pm on Tuesday 26 February.
A red Seat Leon was in collision with a silver Nissan X-Trail.
A Cumbria Police spokesman said: “The driver of the Seat, a 20-year-old local man was airlifted from the scene to the Cumberland Infirmary in Carlisle having suffered serious injuries.
“A 17-year-old male passenger also suffered injuries and was flown to the James Cook Hospital in Middlesbrough although he has now been discharged.
“A 53-year-old female driver of the Nissan, who was also from the local area was taken to hospital by land ambulance suffering a limb injury.
“The road was closed for collision investigation work which took place throughout the evening.”
Police are asking for any witnesses to contact PC1904 Lewis at the Mobile Support Group in Workington by calling 101 quoting log 156 of 26 February.
