The West Coast Mainline between Carlisle and Scotland has been closed.
Avanti, which runs the train service, said due to expected heavy rain bringing adverse weather conditions in Scotland, the line will be closed today until noon tomorrow.
As a result, there are changes to its services between Preston and Carlisle.
Avanti will be operating an amended timetable between Preston and Carlisle with an hourly service.
Journeys between these stations may be subject to further alterations as a result of the heavy rain forecast in Lancashire and Cumbria, it added.